How flavonoids can help with both cellulite and hemorrhoids

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• Flavonoids for blood vessel support, including haemorrhoids and cellulite

• Flavonoids to the rescue of blood vessels

• Reduction in symptoms in 84-100% of participants

• Results with one gram of flavonoids per day for 7 days

• Supplementation, hydration and diet for hemorrhoids, whole body blood vessel support and cellulite

• Should I use a hemorrhoid cream for cellulite?

• Evaluation of the Efficacy and Safety of a Compound of Micronized Flavonoids in Combination With Vitamin C and Extracts of Centella asiatica, Vaccinium myrtillus, and Vitis vinifera for the Reduction of Hemorrhoidal Symptoms in Patients With Grade II and III Hemorrhoidal Disease: A Retrospective Real-Life Study

• Check our professional consultancy, for a masterclass in radiofrequency, ultrasound cavitation, cellulite and skin tightening

Flavonoids for blood vessel support, including haemorrhoids and cellulite

• Polyphenols such as flavonoids are widely researched for this blood vessel supporting and microcirculation boosting action

• This can help in all conditions affected by poor circulation, anything from water retention to cellulite reduction to haemorrhoid improvement: the key issue is exactly the same: blood and lymphatic vessel integrity and function

• This study shows that supplementation with the combination of diosmin, centella asiatica/gotu kola, hesperidin, diosmin, grape seed extract, bilberry, quercetin, rutin, as well as vitamin C, all known for their venotonic action, improve haemorrhoid symptoms at least by one grade

• The supplement’s active ingredient list reads like an “all star list” for supplementation to improve blood vessel health, water retention and cellulite

• Alternatively, you can increase your intake of foods rich in the above, such as citrus fruit, buckwheat, capers, and berries - and enjoy some gotu kola tea too

• Gotu kola, hesperidin, rutin and vitamin C are also included in a small number of quality cellulite / skincare creams

Full analysis follows below.

Flavonoids to the rescue of blood vessels

Hemorrhoidal disease (HD), a common condition characterised by inflammation and swelling in the veins located in the anus and rectum, can cause significant discomfort and pain for those affected.

While various treatments have been used for relief of hemorrhoidal symptoms, a recent study has evaluated the efficacy and safety of a compound made up of micronised flavonoids in combination with vitamin C and extracts of centella asiatica, vaccinium myrtillus (blueberry), and vitis vinifera (grape seed) for the treatment of grade II and III hemorrhoidal disease.

Reduction in symptoms in 84-100% of participants

The use of flavonoids and micronised purified flavonoid fractions (MPFF) for the treatment of HD has been previously reported, with several studies showing positive results after 7 days of therapy.

For example, one study found that 84% of patients with HD experienced pain resolution and 95% experienced bleeding resolution after treatment with MPFF.

Another study found that:

• 98% of patients experienced bleeding improvement

• 94% experienced pain improvement

• 100% experienced pricking improvement

• 92% experienced oedema improvement

• 100% experienced prolapse improvement after treatment with MPFF

Results with one gram of flavonoids per day for 7 days

The current study, which involved the use of a lower overall dose of flavonoids, consisting of…

• 990 mg of micronised flavonoids

• dry extract of 300 mg of centella asiatica

• dry extract of 200 mg of vitis vinifera

• dry extract of 160 mg of vaccinium myrtillus

• 160 mg of vitamin C

…showed promising results after just 7 days of treatment.

Approximately 90% of patients experienced a reduction in their HD grade, with statistically significant improvements seen in all secondary outcomes as well.

One potential explanation for the success of the flavonoid compound used in the current study may be the synergistic effect between its active ingredients, which are known to improve microcirculation and increase the tone and elasticity of the venous wall.

Additionally, the compound was well tolerated, with no adverse events reported and high compliance from patients, who took the compound as one sachet or two tablets per day.

While the results of this study are promising, further research is needed to confirm the findings and determine the optimal dosing and duration of treatment.

Supplementation, hydration and diet for hemorrhoids, whole body blood vessel support and cellulite

However, the use of a flavonoid compound in combination with vitamin C and extracts of centella asiatica, vaccinium myrtillus, and vitis vinifera may offer a safe and effective option for the treatment of grade II and III hemorrhoidal disease.

It is important to note that the treatment of haemorrhoids may involve a combination of lifestyle changes, such as increasing fibre intake, avoiding chilli peppers or black/green pepper added to food, and staying hydrated, as well as medical interventions.

The same interventions will help with whole body blood vessel support, water retention and cellulite reduction/prevention.

A topical cream or gel with the above ingredients can also be useful not just for haemorrhoids but also for cellulite, which is significantly affected by poor blood vessel health and function.

(Of course, individuals experiencing symptoms of hemorrhoids, such as bleeding, pain, itching, and discomfort, should consult with a healthcare professional for proper diagnosis and treatment recommendations.)

Should I use a hemorrhoid cream for cellulite?

That’s a common question and makes sense as the two conditions are to some extent related.

The problem is that hemorrhoid creams are either not that concentrated or well-absorbed by the skin of the thighs and buttocks.

So your best bet is to use a real cellulite cream, i.e. one with multiple, high-purity anti-cellulite actives in high concentrations.

Anti-cellulite and anti-hemorrhoid actives are quite similar to some extent, i.e. gotu kola/centella asiatica, hesperidin, rutin and vitamin C, as mentioned above. But for cellulite the addition of lipolytic actives, such as caffeine and forskolin is essential.

Evaluation of the Efficacy and Safety of a Compound of Micronized Flavonoids in Combination With Vitamin C and Extracts of Centella asiatica, Vaccinium myrtillus, and Vitis vinifera for the Reduction of Hemorrhoidal Symptoms in Patients With Grade II and III Hemorrhoidal Disease: A Retrospective Real-Life Study

• Research paper link: https://pubmed.ncbi.nlm.nih.gov/34970145/

• Abstract: Background and Aim: Several evidences have shown how, in hemorrhoidal disease, phlebotonic flavonoid agents such as quercetin reduce capillary permeability by increasing vascular walls resistance, how rutin and vitamin C have antioxidant properties, and that Centella asiatica has reparative properties towards the connective tissue. A retrospective study was designed in order to evaluate the efficacy and safety of a compound consisting of micronized flavonoids in combination with vitamin C and extracts of C. asiatica, Vaccinium myrtillus, and Vitis vinifera for grade II and III hemorrhoidal disease. Patients and Methods: Data of 49 patients, over 18, who were following a free diet regimen, not on therapy with other anti-hemorrhoid agents, treated with a compound consisting of 450 mg of micronized diosmin, 300 mg of C. asiatica, 270 mg of micronized hesperidin, 200 mg of V. vinifera, 160 mg of vitamin C, 160 mg of V. myrtillus, 140 mg of micronized quercetin, and 130 mg of micronized rutin (1 sachet or 2 tablets a day) for 7 days were collected. Hemorrhoid grade according to Goligher's scale together with anorectal symptoms (edema, prolapse, itching, thrombosis, burning, pain, tenesmus, and bleeding) both before treatment (T0) and after 7 days of therapy (T7) were collected. Primary outcomes were the reduction of at least one degree of hemorrhoids according to Goligher's scale assessed by proctological examination and compound safety. The secondary outcome was the reduction of anorectal symptoms assessed by questionnaires administered to patients. Results: Forty-four patients (89.8%) presented a reduction in hemorrhoidal grade of at least one grade (p < 0.001). No adverse events with the use of the compound were noted. A significant reduction was observed in all anorectal symptoms evaluated (p < 0.05). No predictors of response to the compound were identified among the clinical and demographic variables collected. Conclusion: The compound analyzed was effective and safe for patients with grade II and III hemorrhoidal disease according to Goligher's scale.

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