“My research in anti-ageing, cellulite reduction and skin tightening, as well as my background in nutrition, led me to discover the amazing properties of polyphenols, including resveratrol and pterostilbene. Pterostilbene is indeed more absorbable and more effective than resveratrol in all aspects, including anti-ageing, hyperpigmentation reduction and protection from free radicals, and this is one of the studies that prove this claim.”
Pterostilbene vs resveratrol for hyperpigmentation: which is more effective?
Pterostilbene vs resveratrol for skin lightening and to counter hyperpigmentation | In summary
Pterostilbene and resveratrol as safe and effective anti-pigmentation agents
Resveratrol, pterostilbene, tyrosinase and melanin reduction after UV exposure
Pterostilbene Inhibits the Melanogenesis Activity in UVB-Irradiated B164A5 Cells
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Pterostilbene vs resveratrol for skin lightening and to counter hyperpigmentation | In summary
Pterostilbene is the most biologically active form of resveratrol and one of the most important anti-ageing active molecules
Pterostilbene is known for its skin lightening activity and this cell study has found it to inhibit melanogenesis after UVB exposure (the part of the sun’s UV radiation that causes tanning / pigmentation), 10x times more potent that resveratrol
This study, in combination with multiple others, shows that pterostilbene is better than resveratrol and ideal as an anti-ageing, skin lightening and anti-hyperpigmentation natural molecule, as long as it is used in high purity form (95% purity or higher) and in high concentration (not the usual 0.01% dilution in the vast majority of skincare products)
Pterostilbene is naturally found in black grapes, berry fruits and several plants
Pterostilbene and resveratrol as safe and effective anti-pigmentation agents
Pterostilbene is a resveratrol analog found in plants that has strong antioxidant and anti-inflammatory properties. These properties make it potentially useful for preventing skin cancer and other skin conditions.
However, until recently, there had not been any research examining the effects of pterostilbene on pigment production in the skin - in contrast to its more widely researched chemical “cousin”, resveratrol.
Pigment production in the skin, also known as melanogenesis, is a process that occurs when the skin is exposed to UV radiation.
The skin produces pigment as a way to protect against the damaging effects of the radiation. However, too much pigment (hyperpigmentation) can cause cosmetic problems, such as uneven skin tone, and may even increase the risk of skin cancer.
Researchers have studied many different compounds for their ability to reduce pigment production, but some of these compounds can have side effects such as allergic reactions, irritation, and even cancer.
Resveratrol is a chemical found in plants that has been shown to be effective at reducing pigment production via inhibiting the activity of an enzyme called tyrosinase. Tyrosinase is an enzyme that plays a key role in melanogenesis.
However, resveratrol is not absorbed well by the body and does not last long in the body, and this can limit its effectiveness.
Pterostilbene is similar to resveratrol and is found in plants such as blueberries and grapes. Pterostilbene is absorbed better by the body and lasts longer than resveratrol.
Resveratrol, pterostilbene, tyrosinase and melanin reduction after UV exposure
This study aimed to examine the effects of pterostilbene on pigment production in cells that had been exposed to UVB radiation.
The researchers used a method called the MTT assay to measure the effects of pterostilbene and resveratrol on cell viability. They found that the IC50 value of pterostilbene, which is a measure of how effective it is at killing skin cancer cells, was 34.0 ± 3.43 µM on UVB-irradiated cells. This value is significantly lower than the IC50 value of resveratrol, which was >100 µM. This means that pterostilbene was much more effective at killing skin cancer cells than resveratrol.
The researchers also used a method called the tyrosinase assay to measure the activity of tyrosinase and a method called Western blot analysis to measure the levels of tyrosinase in the cells. They found that pterostilbene caused a significant, dose-dependent inhibition of tyrosinase activity in the cells. At a concentration of 5 µM, pterostilbene caused a 37.14 ± 2.71% inhibition of tyrosinase activity. At a concentration of 10 µM, it caused a 58.36 ± 6.8% inhibition. This means that pterostilbene was able to significantly reduce the activity of tyrosinase in melanin producing cells (melanocytes).
Finally, the researchers found that pterostilbene was able to significantly reduce the amount of pigment in melanocytes. At a concentration of 10 µM, pterostilbene caused a 27.34 ± 0.98 µg/mL reduction in pigment content. This means that pterostilbene was able to significantly reduce the amount of pigment in the cells.
In conclusion, the results of the study showed that pterostilbene has strong anti-melanogenic properties and is much more effective at reducing pigment production and inhibiting tyrosinase activity than resveratrol. Furthermore, it could potentially be useful for preventing skin cancer and other skin conditions.
Pterostilbene Inhibits the Melanogenesis Activity in UVB-Irradiated B164A5 Cells
Research paper link: https://pubmed.ncbi.nlm.nih.gov/34840540/
Abstract: Pterostilbene is a potent antioxidant and anti-inflammatory agent. However, its chemopreventive effects via anti-tyrosinase activity and inhibitory effects on melanin content have not been reported previously. Hence, this study aimed to investigate the anti-melanogenic activity of pterostilbene on UVB-irradiated B164A5 mouse melanoma cells. The effects of pterostilbene and resveratrol on cell viability were determined by MTT assay, whereas melanin content and tyrosinase assay were employed to assess melanogenesis activity. Western blot analysis was performed to determine the tyrosinase expression. Based on the MTT assay, the IC50 value of pterostilbene on UVB-irradiated B164A5 cells was 34.0 ± 3.43 μM, in comparison to resveratrol (>100 μM). Next, 5 and 10 μM pterostilbene showed a significant dose-dependent inhibition (P < .01) of tyrosinase activity in UVB-irradiated B164A5 cells at 37.14 ± 2.71% and 58.36 ± 6.8%, respectively. The findings from the tyrosinase assay also confirmed the downregulation of tyrosinase expression in UVB-irradiated B164A5 cells as measured by Western blot analysis. Finally, 10 μM pterostilbene showed a significantly decreased melanin content (P < .01) in UVB-irradiated B164A5 cells, at 27.34 ± .98 μg/mL. In conclusion, pterostilbene showed anti-melanogenic activity that was 10 times more potent than resveratrol in the UVB-irradiated B164A5 cell.
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