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Decoding lipedema: from hidden causes to hopeful treatments

Decoding lipedema: from hidden causes to hopeful treatments

Lipedema is a chronic condition characterised by abnormal fat deposition primarily in the arms, hips, buttocks, and thighs, while sparing the hands and feet. For decades little was known about this condition but in the last two decades and especially since 2015 research into lipedema as well as awareness by doctors and patients has increased exponentially. Lipoedema, first described in 1910 by Irving Phillips Lyon as "adipose" or "lipomatosis," was formally delineated in 1940 by Edgar Allen and Edgar Alphonso Hines Jr. as a distinct syndrome involving fat legs and orthostatic edema. Symptoms include pain, bruising, edema, and subcutaneous nodules, which are resistant…

Astaxanthin and collagen synergy for cellulite and skin elasticity

Astaxanthin and collagen synergy for cellulite and skin elasticity

It is well known that hydrolysed collagen enhances skin firmness, as it provides peptides which are ready for use by skin cells in the production of collagen. Furthermore, it is also well-known that most "antioxidants" (polyphenols and carotenoids) assist in the prevention of collagen and elastin damage and boost it's production…

Hyaluronic acid: anti-aging, cellulite, weight gain, weight loss, water retention and more...

Hyaluronic acid: anti-aging, cellulite, weight gain, weight loss, water retention and more...

Everyone is talking about hyaluronic acid. I have been researching and formulating skin products with hyaluronic acid (HA) since 2003 and I have seen HA starting to gain wider popularity from 2010 onwards. In the last five years hyaluronic acid has become the most well-known cosmetic active ingredient. But what is hyaluronic acid, what does it do, how does it work and what is really the best type of hyaluronic acid?

The 500 Dalton rule for skincare product absorption

The 500 Dalton rule for skincare product absorption

Do skincare and cellulite creams get absorbed? We analysed the subject of natural skincare active ingredient absorption in detail earlier. This article is specifically of one aspect of cosmetic active absorption: the 500 Dalton rule.

Red (and infrared) light therapy: all you need to know

Red (and infrared) light therapy: all you need to know

Infrared and red light therapy, often termed photobiomodulation and mostly applied via LEDs, is a non-invasive treatment that employs specific wavelengths of light to stimulate healing and address a variety of health and aesthetic conditions. This innovative therapy has surged in popularity in the last decade, celebrated for its efficacy, safety, and adaptability. In this article, we will explore the scientific foundations of red and infrared LED light therapy, clarifying its mechanisms, its multiple health benefits and the practical considerations for its application…

Acoustic wave therapy: cellulite is not a good application for it

Acoustic wave therapy: cellulite is not a good application for it

What is now euphemistically called acoustic wave therapy (AWT) goes by several other names: pressure wave therapy, extracorporeal shockwave therapy (ESWT, the correct name and the original one coined by scientists), shockwave therapy (the shortened version of the correct name) and lipotripsy (the most ridiculous one I have seen). Before shockwaves were used for (questionable) cellulite removal, they were initially used to break down kidney and gallbladder stones, hence the medical name lithotripsy, meaning breaking down stones. From that, one crafty marketer coined the term “lipotripsy”, i.e. breaking down fat, although shockwaves do NOT physically break down fat…

Foods that reverse glycation: cranberry juice polyphenols, skin aging and cellulite

Foods that reverse glycation: cranberry juice polyphenols, skin aging and cellulite

Glycation is one of the main aspects and causes of cellulite and skin ageing. Glycation is caused when sugars bond with collagens (there are 28 types of collagen in the human body). The end results of sugar-collagen bonding are called advanced glycation-end products (AGEs).

Cellulite laser treatment: does it work?

Cellulite laser treatment: does it work?

There are three types of lasers used for cellulite and skin tightening: hot lasers, i.e. high energy lasers; cold lasers, i.e. low energy lasers and also known as low level laser therapy / LLLT; surgical/invasive lasers. Here we present an analysis of all three types of lasers used for cellulite removal and their effectiveness.

How red/infrared light therapy fights skin and whole body inflammation

How red/infrared light therapy fights skin and whole body inflammation

Red/infrared light therapy works by shining light on the body, where it’s absorbed by specific molecules called chromophores. One key chromophore is cytochrome c oxidase, found in the mitochondria—the powerhouses of cells that produce energy. When red (about 630nm) or infrared light (about 830nm) hits this molecule, it boosts energy production by increasing ATP (adenosine triphosphate), the cell’s energy currency. It also causes a small burst of reactive oxygen species (ROS), which are molecules that can signal changes in the cell. Other chromophores include calcium ion channels, which might respond to blue or green light, and water molecules, which absorb infrared light. All these interactions lead to a chain reaction: ATP rises, ROS briefly spikes, and nitric oxide increases, all helping cells function better and reducing inflammation…

Does drinking water help with cellulite?

Does drinking water help with cellulite?

It’s official: according to a study published in The Lancet and detailed below, drinking lots of water throughout your life helps ward off body ageing and degenerative diseases - and their respective subsets: skin ageing and cellulite. Women should aim to drink 2-3 litres of water and non-caffeinated drinks and men should aim for 3-4 litres a day. Still or sparkling, makes no difference. Contrary to popular belief, sparkling water does NOT cause cellulite. But please do not count sugary/sweetened fizzy drinks, juices and juice drinks, as part of this advice.

Cellulite is an inflammatory fat tissue, similar to visceral fat

Cellulite is an inflammatory fat tissue, similar to visceral fat

Of course cellulite does NOT protect from stroke and dementia (contrary to tabloid clickbait articles). Visceral fat is an inflammatory fat tissue that can cause conditions such as stroke and dementia, while subcutaneous fat is more innocuous. However, cellulite is NOT subcutaneous fat…

BPA, microplastics, nanoplastics, forever chemicals, endocrine disruption and cellulite

BPA, microplastics, nanoplastics, forever chemicals, endocrine disruption and cellulite

Do you want smooth, cellulite-free legs? Detoxify your life from endocrine disrupting chemicals, xenoestrogens, phthalates and BPA, found in plastics…

Hidden plastics in chewing gums: a microplastics and endocrine disruptor nightmare for cellulite

Hidden plastics in chewing gums: a microplastics and endocrine disruptor nightmare for cellulite

Surprisingly, the types of plastics found - such as polyolefins, polyethylene terephthalates, polyacrylamides, and polystyrenes - were the same in both natural and synthetic gums, with polyolefins being the most common. Most microplastics were released within the first two minutes of chewing, not due to saliva enzymes but from the abrasive action of chewing itself. After eight minutes, 94% of the detectable microplastics had detached. The study suggests chewing a single piece for longer rather than switching to a new one could reduce exposure. Cellulite, influenced by estrogenic endocrine disruptors, may worsen with microplastics from chewing gum, as these particles can mimic hormones like oestrogen…

HIIT, interval training and uphill interval running: the best types of cellulite exercise

HIIT, interval training and uphill interval running: the best types of cellulite exercise

Interval training is by far the best form of exercise for cellulite reduction and prevention. This is because during the bursts of high intensity activity you burn calories very fast - much faster than you would with slow intensity work. In addition, those bursts act as a shock on the endocrine system and boost your metabolism much more effectively than slow intensity exercise, so you continue to burn calories after your training session…

The artificial sweetener sucralose could lead to weight gain and make cellulite worse

The artificial sweetener sucralose could lead to weight gain and make cellulite worse

In recent years, many people have turned to non-caloric sweeteners like sucralose to enjoy sweet tastes without adding calories to their diet. These sweeteners are popular for weight management, but there’s growing debate about whether they might actually affect hunger and health in unexpected ways. This study explores how sucralose impacts the brain’s appetite control compared to regular sugar (sucrose) and water. The research focuses on a part of the brain called the hypothalamus, which helps regulate hunger, and examines how it reacts differently in people with varying body weights - healthy weight, overweight, and obese - and how it can indirectly affect cellulite…

Spot fat reduction with exercise - does it exist?

Spot fat reduction with exercise - does it exist?

Looking for exercises to reduce cellulite/fat on a specific part of your body like your butt, thighs or stomach? Well, stop looking, because those exercises DO-NOT-EXIST. They don’t. Forget what the tabloid newspaper, glossy magazine, instagram post, exercise blog, youtube vlog or tiktok reel says. It’s all misinformation based on IGNORANCE - or just good, old, plain lying (sorry, I have to call it out as what it is: LYING). Very simply, it is physiologically impossible to reduce fat (including cellulite fat) from a SPECIFIC part of the body with…

Can infrared led light therapy enhance lymphatic drainage and fluid balance?

Can infrared led light therapy enhance lymphatic drainage and fluid balance?

At its core, infrared light therapy employs light-emitting diodes (LEDs) to emit wavelengths typically ranging from 700 to 1,000 nanometers. Unlike the harsh ultraviolet rays that scorch the skin, infrared light penetrates deeper into tissues, reaching muscles, nerves, and even lymphatic structures. The mechanism hinges on stimulating mitochondria—the powerhouses of cells—to produce more adenosine triphosphate (ATP), the molecule that fuels cellular activity…

The connection between cellulite and hemorrhoids - and the flavonoids that can help both

The connection between cellulite and hemorrhoids - and the flavonoids that can help both

Polyphenols such as flavonoids are widely researched for this blood vessel supporting and microcirculation boosting action. This can help in all conditions affected by poor circulation, anything from water retention to cellulite reduction to haemorrhoid improvement: the key issue is exactly the same: blood and lymphatic vessel integrity and function…

Red vine leaf extract improves chronic venous insufficiency [Research]

Red vine leaf extract improves chronic venous insufficiency [Research]

Chronic venous insufficiency (CVI) is common in women, especially older or overweight women. Common symptoms include fat accumulation under/inside the skin, oedema (water retention), heavy legs, muscle cramps, pain and varicose veins. Several natural supplements are used for CVI which can help relieve symptoms of the condition, including centella asiatica/gotu kola extract, hesperidin, diosmin, butcher’s broom extract and escin/horse chestnut extract and red vine leaf extract among others.

Asiaticoside from Gotu kola reverses senescence and oxidative damage in blood vessels

Asiaticoside from Gotu kola reverses senescence and oxidative damage in blood vessels

Asiaticoside and the other three centella asiatica active molecules (asiatic acid, madecassic acid, asiaticoside and madecassoside) are known for their multiple action against whole body ageing, skin ageing and cellulite. In this new study…